RESUMO
OBJECTIVE: The aim of the present study was to explore the relation between lung function and serum retinol (SR) in cystic fibrosis (CF) patients. METHODS: This was a cross-sectional study conducted in a group of 98 young patients with CF (6.8-22.3 years), after the exclusion of those with pulmonary exacerbation, vitamin A deficiency, or other risks, from an initial group of 124 cases. RESULTS: Data of forced expiratory volume in 1 second (FEV1) were widely scattered (87.7% ± 16.9%). These were similar in the 78 pancreatic insufficient and 11 pancreatic sufficient patients. SR (56.6 ± 18.4 µg/dL) was >2.5th percentile of healthy people in the whole group, although 31 patients were situated above the 97.5th percentile (higher value: 110 µg/dL). The FEV1 was noticeably higher in these than in those within the normal range (93.6 ± 14.0 vs 85.0 ± 17.6 µg/dL; P < 0.05). The z score of SR correlated positively with FEV1 (r = 0.364; P = 0.000), after adjusting data for sex, age, body mass index, and pancreatic function. The odds ratio for a FEV1 >80% is 3.78 in patients with SR above the 97.5th percentile, versus only 0.26 in those within the normal range. There were no cases with retinol toxicity. CONCLUSIONS: FEV1 of young patients with CF correlates positively with SR, regardless of age, pancreatic function, or nutritional condition. Those with a moderately high retinol (up to 110 µg/dL) maintain the best respiratory function (FEV1 ≥80% in >90% of them) without any signs of toxicity.
Assuntos
Fibrose Cística/sangue , Fibrose Cística/fisiopatologia , Pulmão/fisiopatologia , Regulação para Cima , Vitamina A/sangue , Adolescente , Adulto , Antioxidantes/efeitos adversos , Antioxidantes/análise , Antioxidantes/uso terapêutico , Índice de Massa Corporal , Criança , Estudos de Coortes , Estudos Transversais , Fibrose Cística/dietoterapia , Suplementos Nutricionais/efeitos adversos , Insuficiência Pancreática Exócrina/etiologia , Feminino , Volume Expiratório Forçado , Humanos , Masculino , Razão de Chances , Estresse Oxidativo , Estudos Prospectivos , Magreza/etiologia , Vitamina A/efeitos adversos , Vitamina A/uso terapêutico , Adulto JovemRESUMO
Informaciones y recomendaciopnes nutricionales para el lactante. Trae además informaciones como las funciones digestivas del lactante, requerimientos nutricionales como las proteínas y aminoácidos esenciales en el primer año de vida, la lactancia materna, la diversificación alimentaria y cual la edad de introdución de alimentos. Documento en formato PDF, requiere Acrobat Reader.
Assuntos
Lactente , Fenômenos Fisiológicos da Nutrição do Lactente , Bem-Estar do Lactente , 24439 , Ciências da NutriçãoRESUMO
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